Bioinformatics Experience
I have completed the
BS Bioinformatics program at
Brigham Young University.
My experiences and projects in areas of computational biology are summarized below.
For a project at Duke with Alex Hartemink and Steve Haase, I have been developing image processing tools to examine yeast cells in microsope images.
MOSAS
Bioinformatics Programming
Fall 2006 - present
I have headed up work on this web-based bioinformatics tools website. Many bioinformaticians struggle with storage and organization of sequences. This an online toolbox which provides a user-friendly interface to several programs. One ability of the website is to construct and edit "datasets" to facilitate data organization for large projects. I have also implemented an annotation engine to facilitate my work annotating mitchondrial genomes.
I worked with Dr. Whiting and Hojun Song at BYU to construct phylogenies of Coleoptera based on the mitochondrial genomes we had sequenced. We found problems with base compositional heterogeneity, and I worked on finding a way to overcome the bias.
I worked with Dr. Crandall and Andrew Stacey at BYU on a project which involved simulating populations to detect minor allele frequencies.
MAB Forcefield Programming
Molecular Mechanics
Summer 2007 - Summer 2008
I worked for over a year on programming a united-atom forcefield in C++ for Roche Palo Alto Computational Chemistry group. These calculations include torsion potentials, angle bending potentials, bond stretching potentials, pi charge calculations, and other equations.
From Fall 2006 through Fall 2008, worked in Dr. Whiting's Lab. My work included learning basic PCR techniques, as well as an introduction to genome building using Sequencher. We were working on the
Beetle Tree of Life in association with the NSF-funded
tree of life project. My particular area of work was in sequencing mitochondrial genomes for different species of beetle. This information will later be used to help construct the beetle tree of life.
I created this 3d video of a zinc finger using PyMol. PyMol is a program that is used to visualize proteins in three dimensions. You can rotate the proteins to get a view of what they look like from all anges. PyMol is very powerful and you can control rotation and turning of the molecules. You can create movies of the proteins and export them as a series of PNG files. I used Adobe Premier to construct this movie from the series of PNG files output by PyMol.